Accessibility navigation


Discovery of novel 1,2,4-triazolo-1,2,4-triazines with thiomethylpyridine hinge binders as potent c-Met kinase inhibitors

Dadashpour, S., Kucukkilinc, T. T., Ayazgok, B., Hosseinimehr, S. J., Chippindale, A. ORCID: https://orcid.org/0000-0002-5918-8701, Foroumadi, A. and Irannejad, H. (2019) Discovery of novel 1,2,4-triazolo-1,2,4-triazines with thiomethylpyridine hinge binders as potent c-Met kinase inhibitors. Future Medicinal Chemistry, 11 (10). pp. 1119-1136. ISSN 1756-8927

[img]
Preview
Text - Accepted Version
· Please see our End User Agreement before downloading.

1MB

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.4155/fmc-2018-0412

Abstract/Summary

Mesenchymal-epithelial transition factor HGF/c-Met overactivation is involved in diverse human cancers. Herein, we report the synthesis and biological evaluation of thiomethylpyridine-linked triazolotriazines as c-Met kinase inhibitors.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Chemical Analysis Facility (CAF)
ID Code:82834
Publisher:Future Science Group

Downloads

Downloads per month over past year

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation