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Automated image analysis system for renal filtration barrier integrity of potassium bromate treated adult male albino rat

Kashef, S. M. I., El Hafez, A. A. A. A., Sarhan, N. I., El-Shal, A. O., Ata, M. M., Ashour, A. S., Dey, N., Elnaby, M. M. A. and Sherratt, R. S. ORCID: (2020) Automated image analysis system for renal filtration barrier integrity of potassium bromate treated adult male albino rat. Multimedia Tools and Applications, 79. pp. 7559-7575. ISSN 1573-7721

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To link to this item DOI: 10.1007/s11042-019-08589-8


Potassium bromate (KBrO3) is a potent nephrotoxic agent that leads to a significant decrease in the activities of renal antioxidant capacity, antioxidant loss and restoration of the renal dysfunction. Several measurements are used to examine the kidney status, including the base width of the foot, the slit pore diameter, and the glomerular basement membrane thickness of the kidney. In this work, morphometric analysis based on image processing is carried out to assess the filtration barrier integrity parameters, which indicates the degree of recovery against the nephrotoxic effect of the KBrO3 on the renal cortex of adult male albino rat and assesses the capability of the renal cortex to recover after its cessation. The morphometric methods based proposed image analysis system enabled the identification of the renal status of different groups, namely the control, potassium bromate affected, and the recovered groups, according to the variation of the measured parameters is a powerful tool. The proposed image analysis system provided a radical geometric morphometrics, which includes morphological operations and structuring element processes in order to identify the glomerular filtration barrier and the feet for further measurements in each case study. The results established that the average lengths of the feet in the histological microscopic images are 465.2397 nm, 278.189 nm, and 393.2347 nm for the control, KBrO3 affected rats and the recovered rats; respectively.

Item Type:Article
Divisions:Life Sciences > School of Biological Sciences > Biomedical Sciences
Life Sciences > School of Biological Sciences > Department of Bio-Engineering
ID Code:88044


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