Gaining acceptability for the Bayesian decision-theoretic approach in dose-escalation studiesZhou, Y. and Lucini, M. (2005) Gaining acceptability for the Bayesian decision-theoretic approach in dose-escalation studies. Pharmaceutical Statistics, 4 (3). pp. 161-171. ISSN 1539-1612 Full text not archived in this repository. It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.1002/pst.172 Abstract/SummaryThere has recently been increasing demand for better designs to conduct first-into-man dose-escalation studies more efficiently, more accurately and more quickly. The authors look into the Bayesian decision-theoretic approach and use simulation as a tool to investigate the impact of compromises with conventional practice that might make the procedures more acceptable for implementation. Copyright © 2005 John Wiley & Sons, Ltd.
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