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Nonenveloped eukaryotic virus entry

Jones, I. M. ORCID: and Roy, P. (2021) Nonenveloped eukaryotic virus entry. In: Bamford, D. H. and Zuckerman, M. (eds.) Encyclopedia of Virology 4th edition. Academic Press, Cambridge, M.A., pp. 409-416. ISBN 9780128145166

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To link to this item DOI: 10.1016/B978-0-12-814515-9.00101-6


The virus replication cycle initiates on cell entry, arguably the most crucial step for virus infection. Moreover, the type of cell infected frequently defines the tissue tropism shown by viruses and in consequence the pathology observed. It is also the first point at which virus replication can be blocked making it a focus for intervention strategies aimed at controlling infection. Non-enveloped viruses lack the opportunity to use membrane fusion to effect cell entry and must directly cross the cell membrane to enter the cytoplasm. The mechanisms by which they achieve this are diverse and increasingly, if still incompletely, understood.

Item Type:Book or Report Section
Divisions:Life Sciences > School of Biological Sciences > Biomedical Sciences
ID Code:96900
Publisher:Academic Press

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