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A 25-year review of sequential methodology in clinical studies

Todd, S. (2007) A 25-year review of sequential methodology in clinical studies. Stat Med, 26 (2). pp. 237-52. ISSN 0277-6715

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To link to this article DOI: 10.1002/sim.2763

Abstract/Summary

This paper explores the theoretical developments and subsequent uptake of sequential methodology in clinical studies in the 25 years since Statistics in Medicine was launched. The review examines the contributions which have been made to all four phases into which clinical trials are traditionally classified and highlights major statistical advancements, together with assessing application of the techniques. The vast majority of work has been in the setting of phase III clinical trials and so emphasis will be placed here. Finally, comments are given indicating how the subject area may develop in the future.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Science > School of Mathematical and Physical Sciences > Department of Mathematics and Statistics > Applied Statistics
ID Code:10099
Uncontrolled Keywords:stopping rules , interim analyses , data monitoring , clinical development phases , clinical trials

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