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Synthesis of the ester side chains of some potently antileukemic harringtonia alkaloids from chiral citrates

Ancliff, R.A., Russell, A.T. and Sanderson, A.J. (2006) Synthesis of the ester side chains of some potently antileukemic harringtonia alkaloids from chiral citrates. Chemical Communications, 2006 (30). pp. 3243-3245. ISSN 1359-7345

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To link to this article DOI: 10.1039/b605339d

Abstract/Summary

The selective reduction of one of the three carboxyl groups of two chiral citric acid derivatives to the corresponding aldehydes, under Rosenmund conditions, are reported together with the application of these aldehydes to the syntheses of the ester side chains of some potently antileukemic Cephalotaxus alkaloids e.g. anhydroharringtonine.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:10967
Uncontrolled Keywords:CHRONIC MYELOGENOUS LEUKEMIA, ENANTIOSELECTIVE SYNTHESIS, HOMOHARRINGTONINE, DERIVATIVES, ACIDS

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