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Ligand bridging of the DNA Holliday junction: molecular recognition of a stacked-X four-way junction by a small molecule

Brogden, A.L., Hopcroft, N.H., Searcey, M. and Cardin, C.J. (2007) Ligand bridging of the DNA Holliday junction: molecular recognition of a stacked-X four-way junction by a small molecule. Angewandte Chemie-International Edition, 46 (21). pp. 3850-3854. ISSN 1433-7851

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To link to this item DOI: 10.1002/anie.200603760

Abstract/Summary

Planning a Holliday: A new mode of binding to a stacked-X, four-way Holliday junction is described in which a chromophore molecule binds across the center of the junction and two adenine residues are replaced by the acridine chromophores at either side of the crossover. This binding mode is specific for the Holliday junction and does not cause unwinding of the DNA helices.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:11053
Uncontrolled Keywords:bridging ligands, DNA structures, ligand design, structure elucidation, X-ray diffraction, CRYSTAL-STRUCTURE, G-QUADRUPLEX, BINDING, CELLS, RECOMBINATION, SEQUENCE, POISON

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