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Metal complexes of cyclen and cyclam derivatives useful for medical applications: a discussion based on thermodynamic stability constants and structural data

Delgado, R., Felix, V., Lima, L.M.P. and Price, D.W. (2007) Metal complexes of cyclen and cyclam derivatives useful for medical applications: a discussion based on thermodynamic stability constants and structural data. Dalton Transactions (26). pp. 2734-2745. ISSN 1364-5447

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To link to this item DOI: 10.1039/b704360k

Abstract/Summary

A series of the most common chelators used in magnetic resonance imaging ( MRI) and in radiopharmaceuticals for medical diagnosis and tumour therapy, H(4)dota, H(4)teta, H(8)dotp and H(8)tetp, is examined from a chemical point of view. Differences between 12- and 14-membered tetraazamacrocyclic derivatives with methylcarboxylate and methylphosphonate pendant arms and their chelates with divalent first-series transition metal and trivalent lanthanide ions are discussed on the basis of their thermodynamic stability constants, X- ray structures and theoretical studies.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:11188
Uncontrolled Keywords:ALKALINE-EARTH-METAL, X-RAY CRYSTAL, BEARING BENZYLPHOSPHINATE GROUPS, NUCLEAR-MAGNETIC-RESONANCE, MACROCYCLIC LIGAND DOTA, WATER, EXCHANGE-RATE, IN-VIVO BEHAVIOR, LANTHANIDE COMPLEXES, 1,4,8,11-TETRAAZACYCLOTETRADECANE-1,4,8,11-TETRAACETIC ACID, MOLECULAR-STRUCTURE
Publisher:Royal Society of Chemistry

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