Accessibility navigation


The Mannich reaction of hydrazones: improved reactivity under solvent-free conditions

El Kaim, L., Gautier, L., Grimaud, L., Harwood, L.M. and Michaut, V. (2003) The Mannich reaction of hydrazones: improved reactivity under solvent-free conditions. Green Chemistry, 5 (4). pp. 477-479. ISSN 1463-9262

Full text not archived in this repository.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.1039/b306242b

Abstract/Summary

The Mannich reaction of hydrazones can be performed without solvent by simply mixing the hydrazone with two to three equivalents of a secondary amine and formaldehyde. Best yields and conditions are obtained with p-nitro substituted arylhydrazones. These conditions allow the efficient coupling of simple hydrazones that failed to react in toluene or ethanol solutions.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:11243

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation