The Mannich reaction of hydrazones: improved reactivity under solvent-free conditions
El Kaim, L., Gautier, L., Grimaud, L., Harwood, L.M. and Michaut, V. (2003) The Mannich reaction of hydrazones: improved reactivity under solvent-free conditions. Green Chemistry, 5 (4). pp. 477-479. ISSN 1463-9262
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To link to this article DOI: 10.1039/b306242b
The Mannich reaction of hydrazones can be performed without solvent by simply mixing the hydrazone with two to three equivalents of a secondary amine and formaldehyde. Best yields and conditions are obtained with p-nitro substituted arylhydrazones. These conditions allow the efficient coupling of simple hydrazones that failed to react in toluene or ethanol solutions.