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Morpholinone mediated oxazolone-free C-terminus amide coupling permitting a convergent strategy for peptide synthesis

Harwood, L.M., Mountford, S.J. and Yan, R. (2009) Morpholinone mediated oxazolone-free C-terminus amide coupling permitting a convergent strategy for peptide synthesis. Journal of Peptide Science, 15 (1). pp. 1-4. ISSN 1075-2617

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To link to this article DOI: 10.1002/psc.1080

Abstract/Summary

3-Substituted-5-phenylmorpholinones have been demonstrated to act as N-protected C-terminus activated alpha-amino acids capable of undergoing solution phase N-terminus peptide extension following standard coupling procedures. The N-acylated morpholinones do not undergo epimerisation of the stereocentre of the C-terminus amino acid residue as oxazolone formation is sterically prevented, although C-terminus peptide coupling is still possible. This convergent approach to peptide synthesis is exemplified by the preparation of L-ala-L-ala-L-ala and L-ala-D-ala-L-ala. Copyright (c) 2008 European Peptide Society and John Wiley & Sons, Ltd.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Interdisciplinary centres and themes > Chemical Analysis Facility (CAF)
ID Code:11320
Uncontrolled Keywords:morpholinone, C-terminus, synthesis, oxazalone , STABILIZED AZOMETHINE YLIDS, SOLID-PHASE SYNTHESIS, AMINO-ACID FLUORIDES, LINKER BAL STRATEGY, 1,3-DIPOLAR CYCLOADDITION, DERIVATIVES, ALKYLATION

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