Accessibility navigation


The effect of PEG crystallization on the morphology of PEG/peptide block copolymers containing amyloid beta-peptide fragments

Krysmann, M.J., Funari, S.S., Canetta, E. and Hamley, I.W. (2008) The effect of PEG crystallization on the morphology of PEG/peptide block copolymers containing amyloid beta-peptide fragments. Macromolecular Chemistry and Physics, 209 (9). pp. 883-889. ISSN 1022-1352

Full text not archived in this repository.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.1002/macp.200700605

Abstract/Summary

Ordered nanostructures are observed in the melt and solid state for a series of three peptide/PEG conjugates containing fragments of amyloid beta-peptides. These are conjugated to PEG with (M) over bar (n) = 3 300 g.mol(-1) and a melting temperature T-m = 45-50 degrees C. The morphology at room temperature is examined by AFM and POM. This shows spherulite formation for the weakly fibrillizing KLVFF-PEG sample but fibril formation for FFKLVFF-PEG. The fibrillization tendency of the latter is enhanced by multiple phenylalanine residues. Simultaneous SAXS and WAXS was used to investigate the morphology as a function of temperature. The secondary structure is probed by FTIR.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:11411
Uncontrolled Keywords:block copolymers, microstructure, peptides, small-angle X-ray scattering (SAXS) , POLY(ETHYLENE GLYCOL), ALZHEIMERS-DISEASE, FIBRIL FORMATION, PROTEINS, FIBRILLOGENESIS, BETA-AMYLOID(10-35), SPECTROSCOPY, POLYMERS, CHAINS

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation