Accessibility navigation


Introduction of vinyl and hydroxymethyl functionalities at C-4 of glucose-derived substrates: synthesis of spirocyclic, bicyclic, and tricyclic nucleosides

Maity, J.K., Ghosh, R., Drew, M.G.B., Achari, B. and Mandal, S.B. (2008) Introduction of vinyl and hydroxymethyl functionalities at C-4 of glucose-derived substrates: synthesis of spirocyclic, bicyclic, and tricyclic nucleosides. Journal of Organic Chemistry, 73 (11). pp. 4305-4308. ISSN 0022-3263

Full text not archived in this repository.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.1021/jo8002826

Abstract/Summary

Installing hydroxymethyl and hydroxyethyl substitutions at C-4 through vinylation and hydroboration-oxidation reactions of the C-4 bis-hydroxymethyl derivative of D-glucose based substrate, and inserting heteroatoms thereafter permitted formation of N-, O-, or S-heterocycles leading to [4,5]or [5,5]-spirocycles and a bicyclo[3.3.0]octane product. Some of the spirocycles were converted to spironucleosides under Vorbruggen glycosidation reaction conditions. Similarly, the bicyclic product was elaborated to the corresponding bicyclic nucleoside as well as an unexpected tricyclic nucleoside.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:11453
Uncontrolled Keywords:STEREOSELECTIVE-SYNTHESIS, SPIRONUCLEOSIDES, DERIVATIVES, BASE, STEREOCHEMISTRY, RIBONUCLEOSIDES, (-)-RAUMACLINE, CYCLIZATION, RING

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation