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A synthetic tripeptide as a novel organo-gelator: a structural investigation

Maji, S.K., Malik, S., Drew, M.G.B., Nandi, A.K. and Banerjee, A. (2003) A synthetic tripeptide as a novel organo-gelator: a structural investigation. Tetrahedron Letters, 44 (21). pp. 4103-4107. ISSN 0040-4039

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To link to this item DOI: 10.1016/S0040-4039(03)00839-6

Abstract/Summary

A self-associating synthetic tripeptide [Boc-Ala(1)-Aib(2)-beta-Ala(3)-OMe (Aib: alpha-amino-isobutyric acid, beta-Ala: beta-alanine)] forms thermoreversible transparent gels in various organic solvents and this offers the first example of a peptide gelator whose molecular self-assembly afforded for gelation has been characterised by single-crystal X-ray diffraction and FT-IR and NMR spectroscopic studies. The crystal structure of an analogous synthetic non-gelator tripeptide [Boc-Ala(1)-Gly(2)-beta-Ala(3)-OMe] is also discussed in light of the self-assembly of the gelator tripeptide. (C) 2003 Elsevier Science Ltd. All rights reserved.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:11455
Uncontrolled Keywords:organogelator, Aib, synthetic peptide , LOW-MOLECULAR-WEIGHT, BETA-SHEET TAPES, AMINO-ACIDS, GELLING AGENTS, CHIRAL GELATOR, PEPTIDE, SOLVENTS, GEL, MODEL, ORGANOGELATORS

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