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Water-soluble tripeptide A beta(9-11) forms amyloid-like fibrils and exhibits neurotoxicity

Naskar, J., Drew, M. G. B., Deb, I., Das, S. and Banerjee, A. (2008) Water-soluble tripeptide A beta(9-11) forms amyloid-like fibrils and exhibits neurotoxicity. Organic Letters, 10 (13). pp. 2625-2628. ISSN 1523-7060

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To link to this item DOI: 10.1021/ol8007217

Abstract/Summary

A water-soluble, hydrophilic tripeptide GYE, having sequence identity with the N-terminal segment of amyloid peptides A,beta(9-11), upon self-association exhibits amyloid-like fibrils and significant neurotoxicity towards the Neuro2A cell line. However, the tripeptides GFE and GWE, in which the centrally located tyrosine residue has been replaced by phenylalanine or tryptophan, fail to show amyloidogenic behavior and exhibit little or no neurotoxicity.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:11525
Uncontrolled Keywords:ALZHEIMERS-DISEASE, INFRARED-SPECTROSCOPY, PROTEIN, POLYPEPTIDE, PEPTIDES, FRAGMENT, MODEL

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