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Preparation and ring-opening reactions of N,O-bis(diphenylphosphinyl) hydroxymethylaziridine ('Di-Dpp')

Sweeney, J.B. and Cantrill, A.A. (2003) Preparation and ring-opening reactions of N,O-bis(diphenylphosphinyl) hydroxymethylaziridine ('Di-Dpp'). Tetrahedron, 59 (21). pp. 3677-3690. ISSN 0040-4020

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To link to this item DOI: 10.1016/s0040-4020(03)00551-9

Abstract/Summary

N,O-bis(diphenylphosphinyl)-2-(hydroxymethyl)aziridine ('DiDpp', 1) is efficiently prepared from 2-aminoethane-1,3-diol: this activated aziridine undergoes two sequential reactions with copper(I)-modified Grignard reagents, yielding alpha-branched N-Dpp amines in good yield. (C) 2003 Elsevier Science Ltd. All rights reserved.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:11644
Uncontrolled Keywords:aziridinemethanol, ring-opening, phosphinate, 2,3-EPOXY AMINES, REARRANGEMENT, 2-AZIRIDINEMETHANOLS, AZIRIDINES

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