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Hydrogen-bonded interpolymer complexes as materials for pharmaceutical applications

Khutoryanskiy, V.V. (2007) Hydrogen-bonded interpolymer complexes as materials for pharmaceutical applications. International Journal of Pharmaceutics, 334 (1-2). pp. 15-26. ISSN 0378-5173

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To link to this article DOI: 10.1016/j.ijpharm.2007.01.037

Abstract/Summary

Association of poly(carboxylic acids) and non-ionic polymers in solutions via hydrogen bonding results in formation of novel polymeric materials-interpolymer complexes. These materials can potentially be used for design of novel mucoadhesive dosage forms, development of solid drug dispersions and solubilisation of poorly soluble drugs, encapsulation technologies, preparation of nanoparticles, hydrogels, in situ gelling systems and electrically erodible materials. This review is an attempt to analyse and systematise existing literature on pharmaceutical application of hydrogen-bonded interpolymer complexes. (c) 2007 Elsevier B.V All rights reserved.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy
ID Code:13711
Uncontrolled Keywords:interpolymer complexes, mucoadhesion, solid drug dispersions, multilayered materials, nanoparticles, in situ gelling systems, INTERPENETRATING POLYMER NETWORKS, INDUCED CROSS-LINKING, SITU GELLING, SYSTEM, POLY(ACRYLIC ACID), POLY(ETHYLENE OXIDE), TEMPLATE, POLYMERIZATION, CONTROLLED-RELEASE, SOLID DISPERSION, MEDICINE RELEASE, ETHYLENE-GLYCOL

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