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Mucoadhesive interactions of amphiphilic cationic copolymers based on [2-(methacryloyloxy)ethyl]trimethylammonium chloride

Fefelova, N.A., Nurkeeva, Z.S., Mun, G.A. and Khutoryanskiy, V.V. (2007) Mucoadhesive interactions of amphiphilic cationic copolymers based on [2-(methacryloyloxy)ethyl]trimethylammonium chloride. International Journal of Pharmaceutics, 339 (1-2). pp. 25-32. ISSN 0378-5173

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To link to this article DOI: 10.1016/j.ijpharm.2007.02.019

Abstract/Summary

Three series of water-soluble cationic copolymers have been synthesised by free-radical copolymerisation of [2-(methacryloyloxy)ethyl]-trimethylammonium chloride (MADQUAT) with methyl acrylate (MA), butyl acrylate (BA) and butyl methacrylate (BMA). The interactions between these copolymers and porcine stomach mucin have been studied in aqueous solutions using dynamic light scattering, zeta-potential measurements, turbidimetric titration and transmission electron microscopy (TEM). It was demonstrated that mixing aqueous dispersions of mucin with solutions of the cationic copolymers results in significant changes in size distribution and zeta-potential of its particles. It was found that an increase in the content of hydrophobic groups in copolymers leads to more efficient adsorption of macromolecules on the surface of mucin particles, which evidences the importance of hydrophobic effects in mucoadhesion. The efficiency of mucoadhesive interactions was found to be significantly dependent on pH, which affects the surface charge and aggregation stability of mucin. (C) 2007 Elsevier B.V. All rights reserved.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy
ID Code:13749
Uncontrolled Keywords:cationic polymers, copolymerisation, mucins, mucoadhesion, hydrophobic, effects, drug delivery, POLY(ACRYLIC ACID), GASTRIC MUCIN, CHITOSAN, POLYMERS, MECHANISMS, HYDROGELS

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