Accessibility navigation


Differential cognitive effects of Ginkgo biloba after acute and chronic treatment in healthy young volunteers

Elsabagh, S., Hartley, D.E., Ali, O., Williamson, E.M. and File, S.E. (2005) Differential cognitive effects of Ginkgo biloba after acute and chronic treatment in healthy young volunteers. Psychopharmacology, 179 (2). pp. 437-446. ISSN 0033-3158

Full text not archived in this repository.

To link to this article DOI: 10.1007/s00213-005-2206-6

Abstract/Summary

Acute doses of Ginkgo biloba have been shown to improve attention and memory in young, healthy participants, but there has been a lack of investigation into possible effects on executive function. In addition, only one study has investigated the effects of chronic treatment in young volunteers. This study was conducted to compare the effects of ginkgo after acute and chronic treatment on tests of attention, memory and executive function in healthy university students. Using a placebo-controlled double-blind design, in experiment 1, 52 students were randomly allocated to receive a single dose of ginkgo (120 mg, n=26) or placebo (n=26), and were tested 4h later. In experiment 2, 40 students were randomly allocated to receive ginkgo (120 mg/day; n=20) or placebo (n=20) for a 6-week period and were tested at baseline and after 6 weeks of treatment. In both experiments, participants underwent tests of sustained attention, episodic and working memory, mental flexibility and planning, and completed mood rating scales. The acute dose of ginkgo significantly improved performance on the sustained-attention task and pattern-recognition memory task; however, there were no effects on working memory, planning, mental flexibility or mood. After 6 weeks of treatment, there were no significant effects of ginkgo on mood or any of the cognitive tests. In line with the literature, after acute administration ginkgo improved performance in tests of attention and memory. However, there were no effects after 6 weeks, suggesting that tolerance develops to the effects in young, healthy participants.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy
ID Code:13752
Uncontrolled Keywords:Ginkgo biloba, sustained attention, episodic memory, mood, executive, function, tolerance, TEMPORAL-LOBE EXCISIONS, SPATIAL WORKING-MEMORY, INTACT OLDER-ADULTS, EXTRACT EGB 761, AMYGDALO-HIPPOCAMPECTOMY, OXIDATIVE STRESS, RANDOMIZED, TRIAL, PANAX-GINSENG, DOUBLE-BLIND, PERFORMANCE

Centaur Editors: Update this record

Page navigation