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Organocatalysis with proline derivatives: improved catalysts for the asymmetric Mannich, nitro-Michael and aldol reactions

Cobb, A.J.A., Shaw, D.M., Longbottom, D.A., Gold, J.B. and Ley, S.V. (2005) Organocatalysis with proline derivatives: improved catalysts for the asymmetric Mannich, nitro-Michael and aldol reactions. Organic & Biomolecular Chemistry, 3 (1). pp. 84-96. ISSN 1477-0520

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To link to this item DOI: 10.1039/b414742a

Abstract/Summary

Tetrazole and acylsulfonamide organocatalysts derived from proline have been synthesised and applied to the asymmetric Mannich, nitro-Michael and aldol reactions to give results that are superior to the proline-catalysed counterpart.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy
ID Code:13776
Uncontrolled Keywords:AMINO-ACID-DERIVATIVES, HIGHLY ENANTIOSELECTIVE SYNTHESIS, ALPHA-AMINO, ONE-POT, HIGH-PRESSURE, ALCOHOL DERIVATIVES, AQUEOUS-MEDIA, IONIC LIQUID, KETONES, ALDEHYDES

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