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Antitumor activity of Titanocene Y against freshly explanted human breast tumor cells and in xenografted MCF-7 tumors in mice

Beckhove, P., Oberschmidt, O., Hanauske, A.R., Pampillon, C., Schirrmacher, V., Sweeney, N.J., Strohfeldt, K. and Tacke, M. (2007) Antitumor activity of Titanocene Y against freshly explanted human breast tumor cells and in xenografted MCF-7 tumors in mice. Anti-cancer Drugs, 18 (3). pp. 311-316. ISSN 0959-4973

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To link to this article DOI: 10.1097/CAD.0b013e328010a6f7

Abstract/Summary

Bis-[(p-methoxybenzyl)cyclopentadienyl] titanium dichloride, better known as Titanocene Y, is a newly synthesized transition metal-based anticancer drug. We studied the antitumor activity of Titanocene Y with concentrations of 2.1, 21 and 210 mu mol/l against a freshly explanted human breast cancer, using an in-vitro soft agar cloning system. The sensitivity against Titanocene Y was highly remarkable in the breast cancer tumor in the full concentration range. Titanocene Y showed cell death induction at 2.1 mu mol/l, well comparable to cisplatin, given at a concentration of 1.0 mu mol/l. A further preclinical development of Titanocene Y was warranted and therefore an MCF-7 human breast cancer xenograft nonobese diabetic/severe combined immunodeficient mouse model was used. Titanocene Y was given for 21 days at 30 mg/kg/ day (75% of the maximum tolerable dose of Titanocene Y), which resulted in the reduction of the tumor volume to around one-third, whereas no mouse was lost because of the surprisingly low toxicity of Titanocene Y.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy
ID Code:13790
Uncontrolled Keywords:anticancer drug, breast cancer, cisplatin, human tumor cloning assay, hydridolithiation, MCF-7 xenograft, super hydride, titanocene , SUBSTITUTED ANSA-TITANOCENE, POTENTIAL ANTICANCER DRUGS, TITANIUM DICHLORIDE, ORGANIC-CHEMISTRY, FULVENES, METALLOCENES, COMPLEXES, AGENTS, CISPLATIN, CANCER

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