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Assessing the accuracy of a computerized decision support system for digoxin dosing in primary care: an observational study

Kroese, W. L. G., Avery, A. J., Savelyich, B. S. P., Brown, N. S., Schers, H., Howard, R., Hippisley-Cox, J. and Horsfield, P. (2005) Assessing the accuracy of a computerized decision support system for digoxin dosing in primary care: an observational study. Journal of Clinical Pharmacy and Therapeutics, 30 (3). pp. 279-283. ISSN 1365-2710

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To link to this item DOI: 10.1111/j.1365-2710.2005.00650.x


Background: This study was carried out as part of a European Union funded project (PharmDIS-e+), to develop and evaluate software aimed at assisting physicians with drug dosing. A drug that causes particular problems with drug dosing in primary care is digoxin because of its narrow therapeutic range and low therapeutic index. Objectives: To determine (i) accuracy of the PharmDIS-e+ software for predicting serum digoxin levels in patients who are taking this drug regularly; (ii) whether there are statistically significant differences between predicted digoxin levels and those measured by a laboratory and (iii) whether there are differences between doses prescribed by general practitioners and those suggested by the program. Methods: We needed 45 patients to have 95% Power to reject the null hypothesis that the mean serum digoxin concentration was within 10% of the mean predicted digoxin concentration. Patients were recruited from two general practices and had been taking digoxin for at least 4 months. Exclusion criteria were dementia, low adherence to digoxin and use of other medications known to interact to a clinically important extent with digoxin. Results: Forty-five patients were recruited. There was a correlation of 0·65 between measured and predicted digoxin concentrations (P < 0·001). The mean difference was 0·12 μg/L (SD 0·26; 95% CI 0·04, 0·19, P = 0·005). Forty-seven per cent of the patients were prescribed the same dose as recommended by the software, 44% were prescribed a higher dose and 9% a lower dose than recommended. Conclusion: PharmDIS-e+ software was able to predict serum digoxin levels with acceptable accuracy in most patients.

Item Type:Article
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmacy Practice Research Group
ID Code:15735
Uncontrolled Keywords:Computerized Support SYSTEM Digoxin primary care PRIMARY-CARE CARE Study STUDIES

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