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Non-promoting diterpene esters can induce Epstein-Barr Virus early antigen expression in the Raji cell line

Evans, A.T., Brooks, G. and Evans, F.J. (1990) Non-promoting diterpene esters can induce Epstein-Barr Virus early antigen expression in the Raji cell line. Cancer Letters, 49 (1). pp. 25-29. ISSN 0304-3835

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To link to this article DOI: 10.1016/0304-3835(90)90135-K

Abstract/Summary

A range of diterpene ester ligands with selective biological activity (e.g., irritant but not tumour promoting) were tested for their ability to induce Epstein-Barr virus (EBV) early antigen expression in the lymphoblastoid Raji cell line. All substituted compounds were found to be capable of inducing some antigen expression at nM−μM levels, including desacetyl-α-sapinine, a compound largely devoid of biological activity. The non-promoting, fluorescent compound, sapintoxin A, was virtually equipotent with promoting compounds. It was concluded that, although the assay has relevance to the specific condition of chronic diterpene ester exposure occurring in conjunction with high EBV infection rates, there was relatively poor correlation with mouse skin tumour promoting potential.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences > Biomedical Sciences
No Reading authors. Back catalogue items
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
ID Code:16116
Uncontrolled Keywords:Epstein-Barr virus; early antigen; phorbol ester; daphnane orthoester; tumour promotion
Publisher:Elsevier

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