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Self-immolative linkers in polymeric delivery systems

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Blencowe, C. A., Russell, A. T., Greco, F., Hayes, W. and Thornthwaite, D. W. (2011) Self-immolative linkers in polymeric delivery systems. Polymer Chemistry, 2 (4). pp. 773-790. ISSN 1759-9954

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To link to this article DOI: 10.1039/C0PY00324G

Abstract/Summary

There has been significant interest in the methodologies of controlled release for a diverse range of applications spanning drug delivery, biological and chemical sensors, and diagnostics. The advancement in novel substrate-polymer coupling moieties has led to the discovery of self-immolative linkers. This new class of linker has gained popularity in recent years in polymeric release technology as a result of stable bond formation between protecting and leaving groups, which becomes labile upon activation, leading to the rapid disassembly of the parent polymer. This ability has prompted numerous studies into the design and development of self-immolative linkers and the kinetics surrounding their disassembly. This review details the main concepts that underpin self-immolative linker technologies that feature in polymeric or dendritic conjugate systems and outlines the chemistries of amplified self-immolative elimination.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:16420
Publisher:Royal Society of Chemistry

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