Accessibility navigation


Refinement of the Clinical Scenario Evaluation Framework for Assessment of Competing Development Strategies with an Application to Multiple Sclerosis

Friede, T., Nicholas, R., Stallard, N., Todd, S. C., Parsons, N., Valdes-Marquez, E. and Chataway, J. (2010) Refinement of the Clinical Scenario Evaluation Framework for Assessment of Competing Development Strategies with an Application to Multiple Sclerosis. Drug Information Journal, 44 (6). pp. 713-718. ISSN 0092-8615

Full text not archived in this repository.

Abstract/Summary

When competing strategies for development programs, clinical trial designs, or data analysis methods exist, the alternatives need to be evaluated in a systematic way to facilitate informed decision making. Here we describe a refinement of the recently proposed clinical scenario evaluation framework for the assessment of competing strategies. The refinement is achieved by subdividing key elements previously proposed into new categories, distinguishing between quantities that can be estimated from preexisting data and those that cannot and between aspects under the control of the decision maker from those that are determined by external constraints. The refined framework is illustrated by an application to a design project for an adaptive seamless design for a clinical trial in progressive multiple sclerosis.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Science > School of Mathematical and Physical Sciences > Department of Mathematics and Statistics > Applied Statistics
Faculty of Science > School of Mathematical and Physical Sciences > Department of Mathematics and Statistics
ID Code:17266
Publisher:Drug Information Association

Centaur Editors: Update this record

Page navigation