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LC-MS & DFT investigations of Cryptolepis sanginolenta root extracts

Ismail, F. M. D., Cox, A. H., Dempster, N. M., Ford, J. L., Dascombe, M. J. and Drew, M. G. B. (2010) LC-MS & DFT investigations of Cryptolepis sanginolenta root extracts. Journal of Pharmacy and Pharmacology, 62 (10). pp. 1489-1490. ISSN 0022-3573

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To link to this article DOI: 10.1111/j.2042-7158.2010.01178.x

Abstract/Summary

The roots of Crytolepis sanguinolenta, a medicinally important ethanobotanical source of the antimalarial cryptolepine, were soxhlet extracted in anaerobic conditions, using hexane then ethanol. Samples of each extract were fractioned using flash chromatography and preparative TLC and compound identity was established using gradient HPLC-positive ion electrospray mass spectrometry. The use of argon depressed the formation of quindoline and hydroxycrytolepine. In addition to known compounds such as cryptolepine, several as yet unidentified compounds remain to be characterised in this root extract.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:18787
Additional Information:Paper presented at Academy of Pharmaceutical Sciences UK-PharmSci 2010, East Midlands Conference Centre, UK. 1-3 September 2010.
Publisher:Royal Pharmaceutical Society

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