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Room temperature synthesis of tri-, tetrasubstituted imidazoles and bis-analogues by mercaptopropylsilica (MPS) in aqueous methanol: application to the synthesis of the drug trifenagrel

Mukhopadhyay, C., Tapaswi, P. K. and Drew, M. G. B. (2010) Room temperature synthesis of tri-, tetrasubstituted imidazoles and bis-analogues by mercaptopropylsilica (MPS) in aqueous methanol: application to the synthesis of the drug trifenagrel. Tetrahedron Letters, 51 (30). pp. 3944-3950. ISSN 0040-4039

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To link to this article DOI: 10.1016/j.tetlet.2010.05.102

Abstract/Summary

The heterogeneous solid catalyst, mercaptopropylsilica (MPS), has been prepared by a modified procedure in water and its structure confirmed by solid state carbon-13 CP-MAS NMR spectrum. This catalyst has been efficiently utilized for the synthesis of a wide variety of tri-, tetrasubstituted imidazoles and their bis-analogues at room temperature. The protocol was further explored for the synthesis of the drug trifenagrel.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:18810
Uncontrolled Keywords:Mercaptopropylsilica (MPS); Heterogeneous catalyst; Recyclable; Room temperature; 2,4,5-Tri- and 1,2,4,5-tetrasubstituted imidazoles; Aqueous methanol; Bis-imidazoles; Trifenagrel
Publisher:Elsevier

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