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Multilayered hydrogel coatings covalently-linked to glass surfaces showing a potential to mimic mucosal tissues

Khutoryanskaya, O., Potgieter, M. and Khutoryanskiy, V. V. (2010) Multilayered hydrogel coatings covalently-linked to glass surfaces showing a potential to mimic mucosal tissues. Soft Matter, 6. pp. 551-556. ISSN 1744-683X

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To link to this article DOI: 10.1039/b918007a

Abstract/Summary

Multilayered hydrogel coatings can be developed on the surface of glass slides via layer-by-layer deposition of hydrogen-bonded interpolymer complexes formed by poly(acrylic acid) and methylcellulose. Chemical modification of the glass surface with (3-aminopropyl)triethoxysilane with subsequent layer-by-layer deposition and cross-linking of interpolymer complexes by thermal treatment allows fabrication of ultrathin hydrogel coatings, not detachable from the substrate. The thickness of these coatings is directly related to the number of deposition cycles and cross-linking conditions. An unusual dependence of the hydrogel swelling properties on the sample thickness is observed and can be interpreted by gradual transitions between two- and three-dimensional networks. The hydrogels exhibit pH-responsive swelling behaviour, achieving higher swelling degrees at pH > 6.0. These coatings can be used as model substrates to study the adhesive properties of pharmaceutical tablets and can potentially mimic the total work of adhesion observed for the detachment of mucoadhesives from porcine buccal mucosa but fail to exhibit identical detachment profiles.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
ID Code:2059
Uncontrolled Keywords:hydrogels, mucoadhesion, interpolymer complexes, layer-by-layer deposition
Publisher:Royal Society of Chemistry

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