A highly oriented cubic phase formed by lipids under shear
Seddon, A. M., Lotze, G., Plivelic, T. S. and Squires, A. M. (2011) A highly oriented cubic phase formed by lipids under shear. Journal of the American Chemical Society, 133 (35). pp. 13860-13863. ISSN 0002-7863
To link to this article DOI: 10.1021/ja2053336
We demonstrate the formation of a macroscopically oriented inverse bicontinuous cubic (QII) lipid phase from a sponge (L3) phase by controlled hydration during shear flow. The L3 phase was the monoolein/ butanediol/water system; the addition of water reduces the butanediol concentration, inducing the formation of a diamond (QIID) cubic phase, which is oriented by the shear flow. The phenomenon was reproduced in both capillary and Couette geometries, indicating that this represents a robust general route for the production of highly aligned bulkQII samples, with applications in nanomaterial templating and protein research.