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Major groove binding and ‘DNA-Induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poisonN-(2-(dimethylamino)ethyl)acridine-4- carboxamide (DACA) into DNA:  X-ray structure complexed to d(CG(5-BrU)ACG)2at 1.3-Å resolution

Todd, A. K., Adams, A., Thorpe, J. H., Denny, W. A., Wakelin, L. P. G. and Cardin, C. J. (1999) Major groove binding and ‘DNA-Induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poisonN-(2-(dimethylamino)ethyl)acridine-4- carboxamide (DACA) into DNA:  X-ray structure complexed to d(CG(5-BrU)ACG)2at 1.3-Å resolution. Journal of Medicinal Chemistry, 42 (4). pp. 536-540. ISSN 0022-2623

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To link to this article DOI: 10.1021/jm980479u


Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:23753
Publisher:American Chemical Society

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