Molybdate and tungstate transfer by rat ileum competitive inhibition by sulphate
Cardin, C. J. and Mason, J. (1976) Molybdate and tungstate transfer by rat ileum competitive inhibition by sulphate. Biochimica et Biophysica Acta (BBA) - Biomembranes, 455 (3). pp. 937-946. ISSN 0005-2736
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To link to this article DOI: 10.1016/0005-2736(76)90062-6
For both MoO42− and WO42− the maximum rate of uptake by the small intestine of the rat (studied in vitro using the everted sac technique) occurs in the lower ileum. Kinetic constants, derived by a least squares procedure, are compared with those previously obtained for SO42− transport. For both and , , with only small differences between sacs IV and V. Mutual inhibition of MoO42− and WO42− transport and inhibition of both by SO42− are competitive processes. This is shown by the generally good agreement between values and derived values and by V values in the presence and absence of the inhibiting species. The three ions SO42−, MoO42− and WO42− are probably transferred across the intestine by a common carrier system. Implications for the sulphate-molybdenum interaction in molybdosis are discussed.