Sulphate transport by rat ileum. Effect of molybdate and other anions
Cardin, C. J. and Mason, J. (1975) Sulphate transport by rat ileum. Effect of molybdate and other anions. Biochimica et Biophysica Acta (BBA) - Biomembranes, 394 (1). pp. 46-54. ISSN 0005-2736
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To link to this item DOI: 10.1016/0005-2736(75)90203-5
Kinetic constants for SO42− transport by upper and lower rat ileum in vitro have been determined by computer fitting of rate vs concentration data obtained using the everted sac technique. MoO42− inhibition of this transport is competitive, and kinetic constants for the inhibition were similarly determined. Transport is also inhibited by the anions WO42−, S2O32− and SeO42−, in the order . These anions have no effect on the transport of l-valine. Low SO42− transport rates were observed in sacs from animals fed a high-molybdenum diet. The significance of the results with respect to the problem of molybdate toxicity in animals is discussed, and related to the known protective effect of SO42−.