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Stabilization of multi-stranded nucleic acid structures using 3'-S-phosphorothiolate linkages

Cosstick, R., Buckingham, J., Brazier, J. and Fisher , J. (2007) Stabilization of multi-stranded nucleic acid structures using 3'-S-phosphorothiolate linkages. Nucleosides Nucleotides & Nucleic Acids, 26 (6-7). pp. 555-558. ISSN 1525-7770

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To link to this article DOI: 10.1080/15257770701490001

Abstract/Summary

3 '-S-Phosphorothiolate linkages incorporated into an oligodeoxynucleotide have been shown to stabilise duplex formation with a complementary RNA strand, but destabilise a duplex formed with a complementary DNA strand. The four-stranded i-motif structure is also stabilised this modification.

Item Type:Article
Refereed:Yes
Divisions:No Reading authors. Back catalogue items
ID Code:27313
Additional Information:Also presented at the 17th International Roundtable of Nucleosides, Nucleotides, and Nucleic Acids

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