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Synthesis of beaded poly(vinyl ether) solid supports with unique solvent compatibility

Greenland, B. W., Liu, S., Cavalli, G., Alpay, E. and Steinke, J. H. (2010) Synthesis of beaded poly(vinyl ether) solid supports with unique solvent compatibility. Polymer, 51 (14). pp. 2984-2992. ISSN 0032-3861

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To link to this item DOI: 10.1016/j.polymer.2010.04.026

Abstract/Summary

Poly(vinyl ether) gels SLURPS (Superior Liquid Uptake Resin for Polymer-supported synthesis) with low cross-linking levels have been synthesized for the first time in beaded form using a non-aqueous inverse suspension polymerisation approach. The synthetic protocol was optimized with regards to several parameters including reactions conditions, type and concentration of suspension stabilizer and controlled low temperature addition of co-initiator. Particle size measurements confirm the production of beads with average diameters of 700e950 mm. Optimization of the monomer composition of the poly (vinyl ether) gels resulted in a novel beaded polymer support with considerably improved as well as unique swelling characteristics in solvents ranging from hexane to water. The synthetic utility of the new gel was confirmed by carrying out a set of transformations with complete conversion leading to a useful amino and hydroxy terminated solid-phase precursor resin. Reaction progress could be monitored easily by 1H and 13C gel-phase NMR.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:29264
Publisher:Elsevier

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