Reversible thermal transition of polydiacetylene based on KTTKS collagen sequence
Palladino, P., Castelletto, V., Dehsorkhi , A., Stetsenko, D. and Hamley, I. W. (2012) Reversible thermal transition of polydiacetylene based on KTTKS collagen sequence. Chemical Communications, 48 (78). pp. 9774-9776. ISSN 1359-7345
To link to this item DOI: 10.1039/c2cc34665f
Here we explore the physico-chemical properties of a peptide amphiphile obtained by chemical conjugation of the collagenstimulating peptide KTTKS with 10,12-pentacosadiynoic acid which photopolymerizes as a stable and extended polydiacetylene. We investigate the self-assembly of this new polymer and rationalize its peculiar behavior in terms of a thermal conformational transition. Surprisingly, this polymer shows a thermal transition associated with a non-cooperative increase in b-sheet content at high temperature.