Asymmetric synthesis of peptidesLaurence M. Harwood / Ran Yan (2012) Asymmetric synthesis of peptides. US 2012/0190816 A9.
It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. Official URL: http://www.google.com/patents/US20120190816 Abstract/SummaryThe present invention provides a process comprising substitution of an acceptor molecule comprising a group -XC(O)- wherein X is O, S or NR8, where R8 is C1-6 alkyl, C6-12 aryl or hydrogen, with a nucleophile, wherein the acceptor molecule is cyclised such that said nucleophilic substitution at -XC (O)- occurs without racemisation. This process has particular application for the production of a peptide by extension from the activated carboxy-terminus of an acyl amino acid residue without epimerisation.
Download Statistics DownloadsDownloads per month over past year Related URLs Deposit Details University Staff: Request a correction | Centaur Editors: Update this record |
Lists
Lists
