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Polymer therapeutics designed for a combination therapy of hormone-dependent cancer

Vicent, M. J., Greco, F., Nicholson, R. I., Paul, A., Griffiths , P. C. and Duncan, R. (2005) Polymer therapeutics designed for a combination therapy of hormone-dependent cancer. Angewandte Chemie-International Edition, 44 (26). pp. 4061-4066. ISSN 1521-3773

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To link to this item DOI: 10.1002/anie.200462960

Abstract/Summary

Designer drug: A polymer therapeutic was designed for a combination therapy of breast cancer. N-(2-Hydroxypropyl)methacrylamide was used as the model polymer platform to prepare a unimolecular polymer conjugate (see picture, radius of gyration: 12.8 nm) that combines an endocrine (the aromatase inhibitor aminoglutethimide, blue) and a chemotherapeutic agent (the anthraxcycline antibiotic doxorubicin, red).

Item Type:Article
Refereed:Yes
Divisions:No Reading authors. Back catalogue items
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
ID Code:31496
Uncontrolled Keywords:Keywords: antitumor agents;drug delivery;drug design;polymers;tumor targeting
Publisher:Wiley-Blackwell

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