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Direct observation of membrane insertion by enveloped virus matrix proteins by phosphate displacement

Neuman, B. W., Kiss, G., Al-Mulla, H. M. N., Dokland, T., Buchmeier, M. J., Weikl, T. and Schley, D. (2013) Direct observation of membrane insertion by enveloped virus matrix proteins by phosphate displacement. PLoS ONE, 8 (2). e57916. ISSN 1932-6203

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Official URL: http://www.plosone.org/article/info%3Adoi%2F10.137...

Abstract/Summary

Enveloped virus release is driven by poorly understood proteins that are functional analogs of the coat protein assemblies that mediate intracellular vesicle trafficking. We used differential electron density mapping to detect membrane integration by membrane-bending proteins from five virus families. This demonstrates that virus matrix proteins replace an unexpectedly large portion of the lipid content of the inner membrane face, a generalized feature likely to play a role in reshaping cellular membranes.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences > Biomedical Sciences
Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > Electron Microscopy Laboratory (CAF)
ID Code:31516
Publisher:Public Library of Science

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