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Collagen stimulating effect of peptide amphiphile C16−KTTKS on human fibroblasts

Jones, R. R., Castelletto, V., Connon, C. J. and Hamley, I. W. (2013) Collagen stimulating effect of peptide amphiphile C16−KTTKS on human fibroblasts. Molecular Pharmaceutics, 10 (3). pp. 1063-1069. ISSN 1543-8392

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To link to this item DOI: 10.1021/mp300549d

Abstract/Summary

The collagen production of human dermal and corneal fibroblasts in contact with solutions of the peptide amphiphile (PA) C16−KTTKS is investigated and related to its self-assembly into nanotape structures. This PA is used in antiwrinkle cosmeceutical applications (trade name Matrixyl). We prove that C16−KTTKS stimulates collagen production in a concentration-dependent manner close to the critical aggregation concentration determined from pyrene fluorescence spectroscopy. This suggests that self-assembly and the stimulation of collagen production are inter-related.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Chemical Analysis Facility (CAF)
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:32307
Uncontrolled Keywords:peptide amphiphile, Matrixyl, collagen, fibroblasts, skincare
Publisher:American Chemical Society

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