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Self-assembly of a peptide amphiphile: transition from nanotape fibrils to micelles

Miravet, J. F., Escuder, B., Segarra-Maset, M. D., Tena-Solsona, M., Hamley, I. W., Dehsorkhi, A. and Castelletto, V. (2013) Self-assembly of a peptide amphiphile: transition from nanotape fibrils to micelles. Soft Matter, 9 (13). pp. 3558-3564. ISSN 1744-683X

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To link to this item DOI: 10.1039/c3sm27899a

Abstract/Summary

A thermal transition is observed in the peptide amphiphile C16-KTTKS (TFA salt) from nanotapes at 20 degrees C to micelles at higher temperature (the transition temperature depending on concentration). The formation of extended nanotapes by the acetate salt of this peptide amphiphile, which incorporates a pentapeptide from type I procollagen, has been studied previously [V. Castelletto et al., Chem. Commun., 2010, 46, 9185]. Here, proton NMR and SAXS provide evidence for the TFA salt spherical micelles at high temperature. The phase behavior, with a Krafft temperature separating insoluble aggregates (extended nanotapes) at low temperature from the high temperature micellar phase resembles that for conventional surfactants, however this has not previously been reported for peptide amphiphiles.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Chemical Analysis Facility (CAF)
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:32308
Publisher:Royal Society of Chemistry

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