Accessibility navigation


A sequential procedure for comparing two experimental treatments with a control

Vincent, E., Todd, S. and Whitehead, J. (2002) A sequential procedure for comparing two experimental treatments with a control. Journal of Biopharmaceutical Statistics, 12 (2). pp. 249-265. ISSN 1054-3406

Full text not archived in this repository.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.1081/BIP-120015747

Abstract/Summary

A procedure is described in which patients are randomized between two experimental treatments and a control. At a series of interim analyses, each experimental treatment is compared with control. One of the experimental treatments might then be found sufficiently superior to the control for it to be declared the best treatment, and the trial stopped. Alternatively, experimental treatments might be eliminated from further consideration at any stage. It is shown how the procedure can be conducted while controlling overall error probabilities. Data concerning evaluation of different doses of riluzole in the treatment of motor neurone disease are used for illustration.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Science > School of Mathematical, Physical and Computational Sciences > Department of Mathematics and Statistics
Faculty of Science > School of Mathematical, Physical and Computational Sciences > Department of Mathematics and Statistics > Applied Statistics
ID Code:33515
Publisher:Taylor & Francis

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation