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Interaction between a cationic surfactant-like peptide and lipid vesicles and its relationship to antimicrobial activity

Dehsorkhi, A., Castelletto, V. and Hamley, I. (2013) Interaction between a cationic surfactant-like peptide and lipid vesicles and its relationship to antimicrobial activity. Langmuir, 29 (46). pp. 14246-14253. ISSN 0743-7463

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To link to this item DOI: 10.1021/la403447u

Abstract/Summary

We investigate the properties of an antimicrobial surfactant-like peptide (Ala)6(Arg), A6R, containing a cationic headgroup. The interaction of this peptide with zwitterionic (DPPC) lipid vesicles is investigated using a range of microscopic, X-ray scattering, spectroscopic, and calorimetric methods. The β-sheet structure adopted by A6R is disrupted in the presence of DPPC. A strong effect on the small-angle X-ray scattering profile is observed: the Bragg peaks from the DPPC bilayers in the vesicle walls are eliminated in the presence of A6R and only bilayer form factor peaks are observed. All of these observations point to the interaction of A6R with DPPC bilayers. These studies provide insight into interactions between a model cationic peptide and vesicles, relevant to understanding the action of antimicrobial peptides on lipid membranes. Notably, peptide A6R exhibits antimicrobial activity without membrane lysis.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Chemical Analysis Facility (CAF)
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:35336
Publisher:American Chemical Society

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