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Multiwalled nanotubes formed by catanionic mixtures of drug amphiphiles

Lin, Y.-A., Cheetham, A. G., Zhang, P., Ou, Y.-C., Li, Y., Liu, G., Hermida-Merino, D., Hamley, I. W. and Cui, H. (2014) Multiwalled nanotubes formed by catanionic mixtures of drug amphiphiles. ACS Nano, 8 (12). pp. 12690-12700. ISSN 1936-086X

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To link to this item DOI: 10.1021/nn505688b

Abstract/Summary

Mixing of oppositely charged amphiphilic molecules (catanionic mixing) offers an attractive strategy to produce morphologies different from those formed by individual molecules. We report here on the use of catanionic mixing of anticancer drug amphiphiles to construct multiwalled nanotubes containing a fixed and high drug loading. We found that the molecular mixing ratio, the solvent composition, the overall drug concentrations, as well as the molecular design of the studied amphiphiles are all important experimental parameters contributing to the tubular morphology. We believe these results demonstrate the remarkable potential that anticancer drugs could offer to self-assemble into discrete nanostructures and also provide important insight into the formation mechanism of nanotubes by catanionic mixtures. Our preliminary animal studies reveal that the CPT nanotubes show significantly prolonged retention time in the tumor site after intratumoral injection.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Chemical Analysis Facility (CAF)
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:39085
Publisher:American Chemical Society

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