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Switchable amplification of vibrational circular dichroism as a probe of local chiral structure

Domingos, S. R., Sanders, H. J., Hartl, F., Buma, W. J. and Woutersen, S. (2014) Switchable amplification of vibrational circular dichroism as a probe of local chiral structure. Angewandte Chemie-International Edition, 53 (51). pp. 14042-14045. ISSN 1521-3773

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To link to this item DOI: 10.1002/anie.201407376

Abstract/Summary

A new method to detect the vibrational circular dichroism (VCD) of a localized part of a chiral molecular system is reported. A local VCD amplifier was implemented, and the distance dependence of the amplification was investigated in a series of peptides. The results indicate a characteristic distance of 2.0±0.3 bonds, which suggests that the amplification is a localized phenomenon. The amplifier can be covalently coupled to a specific part of a molecule, and can be switched ON and OFF electrochemically. By subtracting the VCD spectra obtained when the amplifier is in the ON and OFF states, the VCD of the local environment of the amplifier can be separated from the total VCD spectrum. Switchable local VCD amplification thus makes it possible to “zoom in” on a specific part of a chiral molecule.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Chemical Analysis Facility (CAF)
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:39216
Publisher:Wiley-Blackwell

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