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Combination therapy: opportunities and challenges for polymer-drug conjugates as anticancer nanomedicines.

Greco, F. and Vicent, M. (2009) Combination therapy: opportunities and challenges for polymer-drug conjugates as anticancer nanomedicines. Advanced Drug Delivery Reviews, 61 (13). pp. 1203-1213. ISSN 0169-409X

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To link to this article DOI: 10.1016/j.addr.2009.05.006

Abstract/Summary

The discovery of new molecular targets and the subsequent development of novel anticancer agents are opening new possibilities for drug combination therapy as anticancer treatment. Polymer-drug conjugates are well established for the delivery of a single therapeutic agent, but only in very recent years their use has been extended to the delivery of multi-agent therapy. These early studies revealed the therapeutic potential of this application but raised new challenges (namely, drug loading and drugs ratio, characterisation, and development of suitable carriers) that need to be addressed for a successful optimisation of the system towards clinical applications.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
ID Code:4406
Uncontrolled Keywords:Polymer-conjugate; Polymer therapeutics; Nanomedicine; Targeted drug delivery; Combination therapy; Cancer
Publisher:Elsevier Science BV

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