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Molecular basis of platelet activation by an alphaIIbbeta3-CHAMPS peptide.

Grygielska, B., Hughes, C. E. and Watson, S. P. (2009) Molecular basis of platelet activation by an alphaIIbbeta3-CHAMPS peptide. Journal of thrombosis and haemostasis : JTH, 7 (2). pp. 339-46. ISSN 1538-7836

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Abstract/Summary

The present study demonstrates that the alphaIIb-CHAMPS peptide induces platelet activation through integrin alphaIIbbeta3-dependent and independent pathways with the former mediating tyrosine phosphorylation of FcR gamma-chain and Syk. The use of the alphaIIb-CHAMPS peptide to study integrin alphaIIbbeta3 function is compromised by non-integrin-mediated effects.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences > Biomedical Sciences
ID Code:44579

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