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Items where Author is "Hughes, Dr Craig"

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Gaspar, R. S., Unsworth, A. J., Al-Dibouni, A., Bye, A. P., Sage, T., Stewart, M., Cox, R. D., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352, Sellayah, D. and Hughes, C. ORCID: https://orcid.org/0000-0002-9790-5820 (2021) Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring. Scientific Reports, 11. 1473. ISSN 2045-2322 doi: https://doi.org/10.1038/s41598-020-80373-3

Soriano Jerez, E. M., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 and Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820 (2021) Targeting platelet inhibition receptors for novel therapies: PECAM-1 and G6b-B. Platelets, 32 (6). pp. 761-769. ISSN 0953-7104 doi: https://doi.org/10.1080/09537104.2021.1882668

Nicolson, P. L., Nock, S. H., Hinds, J., Garcia-Quintanilla, L., Smith, C. W., Campos, J., Brill, A., Pike, J. A., Khan, A. O., Poulter, N. S., Kavanagh, D. M., Watson, S., Watson, C. N., Clifford, H., Huissoon, A. P., Pollitt, A. Y. ORCID: https://orcid.org/0000-0001-8706-5154, Eble, J. A., Pratt, G., Watson, S. P. and Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820 (2020) Low dose Btk inhibitors selectively block platelet activation by CLEC-2. Haematologica, 105 (1). ISSN 1592-8721 doi: https://doi.org/10.3324/haematol.2019.218545

Nicolson, P. L. R., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Watson, S., Nock, S. H., Hardy, A. T., Watson, C. N., Montague, S. J., Clifford, H., Huissoon, A. P., Malcor, J.-D., Thomas, M. R., Pollitt, A. Y. ORCID: https://orcid.org/0000-0001-8706-5154, Tomlinson, M. G., Pratt, G. and Watson, S. P. (2018) Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation to GPVI. Haematologica, 103 (12). pp. 2097-2108. ISSN 1592-8721 doi: https://doi.org/10.3324/haematol.2018.193391

Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820 (2018) How to perform aggregometry and lumi-aggregometry in mouse platelets. Platelets, 29 (7). pp. 638-643. ISSN 0953-7104 doi: https://doi.org/10.1080/09537104.2018.1478074

Mangin, P. H., Onselaer, M.-B., Receveur, N., Le Lay, N., Hardy, A. T., Wilson, C., Sanchez, X., Loyau, S., Dupuis, A., Babar, A. K., Miller, J. L. C., Philippou, H., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Herr, A. B., Ariens, R. A., Mezzano, D., Jandrot-Perrus, M., Gachet, C. and Watson, S. P. (2018) Immobilized fibrinogen activates human platelets through GPVI. Hematologica, 103 (5). pp. 898-907. ISSN 1592-8721 doi: https://doi.org/10.3324/haematol.2017.182972

Lombard, S. E., Pollitt, A. Y. ORCID: https://orcid.org/0000-0001-8706-5154, Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Di, Y., Mckinnon, T., O'Callaghan, C. A. and Watson, S. P. (2018) Mouse podoplanin supports adhesion and aggregation of platelets under arterial shear: a novel mechanism of haemostasis. Platelets, 29 (7). pp. 716-722. ISSN 0953-7104 doi: https://doi.org/10.1080/09537104.2017.1356919

Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Unsworth, A. J., Desborough, M. J., Hildyard, C. A. T., Appleby, N., Bruce, D., Kriek, N., Nock, S. H., Sage, T., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820 and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2017) Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib. Blood Advances, 1 (26). pp. 2610-2623. ISSN 2473-9529 doi: https://doi.org/10.1182/bloodadvances.2017011999

Alshehri, O. M., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Montague, S., Watson, S. K., Frampton, J., Bender, M. and Watson, S. P. (2015) Fibrin activates GPVI in human and mouse platelets. Blood, 126 (13). pp. 1601-1608. ISSN 0006-4971 doi: https://doi.org/10.1182/blood-2015-04-641654

Alshehri, O. M., Montague, S., Watson, S., Carter, P., Sarker, N., Manne, B. K., Miller, J. L. C., Herr, A. B., Pollitt, A. Y. ORCID: https://orcid.org/0000-0001-8706-5154, O'Callaghan, C. A., Kunapuli, S., Arman, M., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820 and Watson, S. P. (2015) Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands. Biochemical Journal, 468 (3). pp. 459-473. ISSN 0264-6021 doi: https://doi.org/10.1042/BJ20150192

Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Finney, B. A., Koentgen, F., Lowe, K. L. and Watson, S. P. (2015) The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets. Blood, 125 (1). pp. 144-154. ISSN 0006-4971 doi: https://doi.org/10.1182/blood-2014-05-579375

Cherpokova, D., Bender, M., Morowski, M., Kraft, P., Schuhmann, M. K., Akbar, S. M., Sultan, C. S., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Kleinschnitz, C., Stoll, G., Dragone, L. L., Watson, S. P., Tomlinson, M. G. and Nieswandt, B. (2015) SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice. Blood, 125 (1). pp. 185-194. ISSN 0006-4971 doi: https://doi.org/10.1182/blood-2014-06-580597

Pollitt, A. Y. ORCID: https://orcid.org/0000-0001-8706-5154, Poulter, N. S., Gitz, E., Navarro-Nuñez, L., Wang, Y.-J., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Thomas, S. G., Nieswandt, B., Douglas, M. R., Owen, D. M., Jackson, D. G., Dustin, M. L. and Watson, S. P. (2014) Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells. The Journal of Biological Chemistry, 289 (52). pp. 35695-35710. ISSN 1083-351X doi: https://doi.org/10.1074/jbc.M114.584284

Dütting, S., Vögtle, T., Morowski, M., Schiessl, S., Schäfer, C. M., Watson, S. K., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Ackermann, J. A., Radtke, D., Hermanns, H. M., Watson, S. P., Nitschke, L. and Nieswandt, B. (2014) Growth factor receptor-bound protein 2 contributes to (hem)immunoreceptor tyrosine-based activation motif-mediated signaling in platelets. Circulation Research, 114 (3). pp. 444-453. ISSN 0009-7330 doi: https://doi.org/10.1161/CIRCRESAHA.114.302670

Manne, B. K., Getz, T. M., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Alshehri, O., Dangelmaier, C., Naik, U. P., Watson, S. P. and Kunapuli, S. P. (2013) Fucoidan is a novel platelet agonist for the C-type lectin-like receptor 2 (CLEC-2). The Journal of Biological Chemistry, 288 (11). pp. 7717-7726. ISSN 1083-351X doi: https://doi.org/10.1074/jbc.M112.424473

Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Sinha, U., Pandey, A., Eble, J. A., O'Callaghan, C. A. and Watson, S. P. (2013) Critical role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2). The Journal of Biological Chemistry, 288 (7). pp. 5127-5135. ISSN 1083-351X doi: https://doi.org/10.1074/jbc.M112.411462

Finney, B. A., Schweighoffer, E., Navarro-Núñez, L., Bénézech, C., Barone, F., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Langan, S. A., Lowe, K. L., Pollitt, A. Y. ORCID: https://orcid.org/0000-0001-8706-5154, Mourao-Sa, D., Sheardown, S., Nash, G. B., Smithers, N., Reis e Sousa, C., Tybulewicz, V. L. J. and Watson, S. P. (2012) CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development. Blood, 119 (7). pp. 1747-1756. ISSN 0006-4971 doi: https://doi.org/10.1182/blood-2011-09-380709

Jarvis, G. E., Bihan, D., Hamaia, S., Pugh, N., Ghevaert, C. J. G., Pearce, A. C., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Watson, S. P., Ware, J., Rudd, C. E. and Farndale, R. W. (2012) A role for adhesion and degranulation-promoting adapter protein in collagen-induced platelet activation mediated via integrin α(2) β(1). Journal of Thrombosis and Haemostasis, 10 (2). pp. 268-277. ISSN 1538-7933 doi: https://doi.org/10.1111/j.1538-7836.2011.04567.x

Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Radhakrishnan, U. P., Lordkipanidzé, M., Egginton, S., Dijkstra, J. M., Jagadeeswaran, P. and Watson, S. P. (2012) G6f-like is an ITAM-containing collagen receptor in thrombocytes. PLoS ONE, 7 (12). e52622. ISSN 1932-6203 doi: https://doi.org/10.1371/journal.pone.0052622

Brazón, J., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Mori, J., Sevcik, C., D'suze, G. and Watson, S. P. (2011) Tityus discrepans scorpion venom activates platelets through GPVI and a novel Src-dependent signaling pathway. Platelets, 22 (3). pp. 165-172. ISSN 0953-7104 doi: https://doi.org/10.3109/09537104.2010.544343

Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Navarro-Núñez, L., Finney, B. A., Mourão-Sá, D., Pollitt, A. Y. ORCID: https://orcid.org/0000-0001-8706-5154 and Watson, S. P. (2010) CLEC-2 is not required for platelet aggregation at arteriolar shear. Journal of Thrombosis and Haemostasis, 8 (10). pp. 2328-2332. ISSN 1538-7933 doi: https://doi.org/10.1111/j.1538-7836.2010.04006.x

Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Pollitt, A. Y. ORCID: https://orcid.org/0000-0001-8706-5154, Mori, J., Eble, J. A., Tomlinson, M. G., Hartwig, J. H., O'Callaghan, C. A., Fütterer, K. and Watson, S. P. (2010) CLEC-2 activates Syk through dimerization. Blood, 115 (14). pp. 2947-2955. ISSN 1528-0020 doi: https://doi.org/10.1182/blood-2009-08-237834

Spalton, J. C., Mori, J., Pollitt, A. Y. ORCID: https://orcid.org/0000-0001-8706-5154, Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Eble, J. A. and Watson, S. P. (2009) The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets. Journal of thrombosis and haemostasis : JTH, 7 (7). pp. 1192-9. ISSN 1538-7836

Grygielska, B., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820 and Watson, S. P. (2009) Molecular basis of platelet activation by an alphaIIbbeta3-CHAMPS peptide. Journal of thrombosis and haemostasis : JTH, 7 (2). pp. 339-46. ISSN 1538-7836

Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Auger, J. M., McGlade, J., Eble, J. A., Pearce, A. C. and Watson, S. P. (2008) Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2. Journal of thrombosis and haemostasis : JTH, 6 (12). pp. 2152-9. ISSN 1538-7836

Riba, R., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Graham, A., Watson, S. P. and Naseem, K. M. (2008) Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor gamma chain complex. Journal of thrombosis and haemostasis : JTH, 6 (6). pp. 1012-20. ISSN 1538-7836

Pears, C. J., Thornber, K., Auger, J. M., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Grygielska, B., Protty, M. B., Pearce, A. C. and Watson, S. P. (2008) Differential roles of the PKC novel isoforms, PKCδ and PKCε, in mouse and human platelets. PLoS ONE, 3 (11). e3793. ISSN 1932-6203 doi: https://doi.org/10.1371/journal.pone.0003793

Hughan, S. C., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, McCarty, O. J. T., Schweighoffer, E., Soultanova, I., Ware, J., Tybulewicz, V. L. J. and Watson, S. P. (2007) GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk. Arteriosclerosis, thrombosis, and vascular biology, 27 (2). pp. 422-9. ISSN 1524-4636

Dhanjal, T. S., Ross, E. A., Auger, J. M., McCarty, O. J. T., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Senis, Y. A., Buckley, C. D. and Watson, S. P. (2007) Minimal regulation of platelet activity by PECAM-1. Platelets, 18 (1). pp. 56-67. ISSN 0953-7104

Suzuki-Inoue, K., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Inoue, O., Kaneko, M., Cuyun-Lira, O., Takafuta, T., Watson, S. P. and Ozaki, Y. (2007) Involvement of Src kinases and PLCgamma2 in clot retraction. Thrombosis research, 120 (2). pp. 251-8. ISSN 0049-3848

García, A., Senis, Y. A., Antrobus, R., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Dwek, R. A., Watson, S. P. and Zitzmann, N. (2006) A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter. Proteomics, 6 (19). pp. 5332-43. ISSN 1615-9853

Book or Report Section

Pollitt, A. Y. ORCID: https://orcid.org/0000-0001-8706-5154, Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820 and Watson, S. P. (2013) GPVI and CLEC-2. In: Michelson, A. D. (ed.) Platelets. 3rd edition. Academic Press, Amsterdam, pp. 215-231. ISBN 9780123878373 doi: https://doi.org/10.1016/B978-0-12-387837-3.00011-0

Conference or Workshop Item

Yu, T. Y., Finney, B. A., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Dehghani, H., Claridge, E. and Thomas, S. G. (2013) Three dimensional analysis of cardiovascular development in mouse embryos using X-ray microcomputed tomography. In: Microscopy and Analysis.

Thesis

Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820 (2010) Comparison of CLEC-2 and GPVI signaling in platelets: the role of adaptor proteins. PhD thesis, University of Birmingham.

This list was generated on Fri May 24 21:44:09 2024 UTC.

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