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Items where Author is "Hughes, Dr Craig"

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Gaspar, Renato S., Unsworth, Amanda J., Al-Dibouni, Alaa, Bye, Alexander P., Sage, Tanya, Stewart, Michelle, Cox, Roger D., Gibbins, Jonathan M. ORCID logoORCID:, Sellayah, Dyan and Hughes, Craig ORCID logoORCID: (2021) Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring. Scientific Reports, 11. 1473. ISSN 2045-2322 doi:

Soriano Jerez, Eva M., Gibbins, Jonathan M. ORCID logoORCID: and Hughes, Craig E. ORCID logoORCID: (2021) Targeting platelet inhibition receptors for novel therapies: PECAM-1 and G6b-B. Platelets, 32 (6). pp. 761-769. ISSN 0953-7104 doi:

Nicolson, Phillip LR, Nock, Sophie H, Hinds, Joshua, Garcia-Quintanilla, Lourdes, Smith, Christopher W, Campos, Joana, Brill, Alexander, Pike, Jeremy A, Khan, Abdullah O, Poulter, Natalie S, Kavanagh, Deidre M, Watson, Stephanie, Watson, Callum N, Clifford, Hayley, Huissoon, Aarnoud P, Pollitt, Alice Y, Eble, Johannes A, Pratt, Guy, Watson, Steve P and Hughes, Craig E (2020) Low dose Btk inhibitors selectively block platelet activation by CLEC-2. Haematologica, 105 (1). ISSN 1592-8721 doi:

Nicolson, Phillip L. R., Hughes, Craig E., Watson, Stephanie, Nock, Sophie H., Hardy, Alexander T., Watson, Callum N., Montague, Samantha J., Clifford, Hayley, Huissoon, Aarnoud P., Malcor, Jean-Daniel, Thomas, Mark R., Pollitt, Alice Y., Tomlinson, Michael G., Pratt, Guy and Watson, Steve P. (2018) Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation to GPVI. Haematologica, 103 (12). pp. 2097-2108. ISSN 1592-8721 doi:

Hughes, Craig E. (2018) How to perform aggregometry and lumi-aggregometry in mouse platelets. Platelets, 29 (7). pp. 638-643. ISSN 0953-7104 doi:

Mangin, Pierre H., Onselaer, Marie-Blanche, Receveur, Nicolas, Le Lay, Nicolas, Hardy, Alexander T., Wilson, Clare, Sanchez, Ximena, Loyau, Stephane, Dupuis, Arnaud, Babar, Amir K, Miller, Jeanette L. C., Philippou, Helen, Hughes, Craig E., Herr, Andrew B., Ariens, Robert A., Mezzano, Diego, Jandrot-Perrus, Martine, Gachet, Christian and Watson, Steve P. (2018) Immobilized fibrinogen activates human platelets through GPVI. Hematologica, 103 (5). pp. 898-907. ISSN 1592-8721 doi:

Lombard, Stephanie E., Pollitt, Alice Y., Hughes, Craig E., Di, Ying, Mckinnon, Tom, O'Callaghan, Chris A. and Watson, Steve P. (2018) Mouse podoplanin supports adhesion and aggregation of platelets under arterial shear: a novel mechanism of haemostasis. Platelets, 29 (7). pp. 716-722. ISSN 0953-7104 doi:

Bye, Alex P., Unsworth, Amanda J., Desborough, Michael J., Hildyard, Catherine A. T., Appleby, Niamh, Bruce, David, Kriek, Neline, Nock, Sophie H., Sage, Tanya, Hughes, Craig E. and Gibbins, Jon M. (2017) Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib. Blood Advances, 1 (26). pp. 2610-2623. ISSN 2473-9529 doi:

Alshehri, Osama M., Hughes, Craig E., Montague, Samantha, Watson, Stephanie K., Frampton, Jon, Bender, Markus and Watson, Steve P. (2015) Fibrin activates GPVI in human and mouse platelets. Blood, 126 (13). pp. 1601-1608. ISSN 0006-4971 doi:

Alshehri, Osama M., Montague, Samantha, Watson, Stephanie, Carter, Paul, Sarker, Najiat, Manne, Bhanu K., Miller, Jeanette L. C., Herr, Andrew B., Pollitt, Alice Y., O'Callaghan, Chris A., Kunapuli, Satya, Arman, Mònica, Hughes, Craig E. and Watson, Steve P. (2015) Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands. Biochemical Journal, 468 (3). pp. 459-473. ISSN 0264-6021 doi:

Hughes, Craig E., Finney, Brenda A., Koentgen, Frank, Lowe, Kate L. and Watson, Steve P. (2015) The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets. Blood, 125 (1). pp. 144-154. ISSN 0006-4971 doi:

Cherpokova, Deya, Bender, Markus, Morowski, Martina, Kraft, Peter, Schuhmann, Michael K., Akbar, Sarah M., Sultan, Cheryl S., Hughes, Craig E., Kleinschnitz, Christoph, Stoll, Guido, Dragone, Leonard L., Watson, Steve P., Tomlinson, Michael G. and Nieswandt, Bernhard (2015) SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice. Blood, 125 (1). pp. 185-194. ISSN 0006-4971 doi:

Pollitt, Alice Y., Poulter, Natalie S., Gitz, Eelo, Navarro-Nuñez, Leyre, Wang, Ying-Jie, Hughes, Craig E., Thomas, Steven G., Nieswandt, Bernhard, Douglas, Michael R., Owen, Dylan M., Jackson, David G., Dustin, Michael L. and Watson, Steve P. (2014) Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells. The Journal of Biological Chemistry, 289 (52). pp. 35695-35710. ISSN 1083-351X doi:

Dütting, Sebastian, Vögtle, Timo, Morowski, Martina, Schiessl, Sarah, Schäfer, Carmen M., Watson, Stephanie K., Hughes, Craig E., Ackermann, Jochen A, Radtke, Daniel, Hermanns, Heike M, Watson, Steve P., Nitschke, Lars and Nieswandt, Bernhard (2014) Growth factor receptor-bound protein 2 contributes to (hem)immunoreceptor tyrosine-based activation motif-mediated signaling in platelets. Circulation Research, 114 (3). pp. 444-453. ISSN 0009-7330 doi:

Manne, Bhanu Kanth, Getz, Todd M., Hughes, Craig E., Alshehri, Osama, Dangelmaier, Carol, Naik, Ulhas P., Watson, Steve P. and Kunapuli, Satya P. (2013) Fucoidan is a novel platelet agonist for the C-type lectin-like receptor 2 (CLEC-2). The Journal of Biological Chemistry, 288 (11). pp. 7717-7726. ISSN 1083-351X doi:

Hughes, Craig E., Sinha, Uma, Pandey, Anjali, Eble, Johannes A., O'Callaghan, Christopher A. and Watson, Steve P. (2013) Critical role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2). The Journal of Biological Chemistry, 288 (7). pp. 5127-5135. ISSN 1083-351X doi:

Finney, Brenda A., Schweighoffer, Edina, Navarro-Núñez, Leyre, Bénézech, Cecile, Barone, Francesca, Hughes, Craig E., Langan, Stacey A., Lowe, Kate L., Pollitt, Alice Y., Mourao-Sa, Diego, Sheardown, Steve, Nash, Gerard B., Smithers, Nicholas, Reis e Sousa, Caetano, Tybulewicz, Victor L. J. and Watson, Steve P. (2012) CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development. Blood, 119 (7). pp. 1747-1756. ISSN 0006-4971 doi:

Jarvis, G. E., Bihan, D., Hamaia, S., Pugh, N., Ghevaert, C. J. G., Pearce, A. C., Hughes, Craig E., Watson, S. P., Ware, J., Rudd, C. E. and Farndale, R. W. (2012) A role for adhesion and degranulation-promoting adapter protein in collagen-induced platelet activation mediated via integrin α(2) β(1). Journal of Thrombosis and Haemostasis, 10 (2). pp. 268-277. ISSN 1538-7933 doi:

Hughes, Craig E., Radhakrishnan, Uvaraj P., Lordkipanidzé, Marie, Egginton, Stuart, Dijkstra, Johannes M., Jagadeeswaran, Pudur and Watson, Stephen P. (2012) G6f-like is an ITAM-containing collagen receptor in thrombocytes. PLoS ONE, 7 (12). e52622. ISSN 1932-6203 doi:

Brazón, Josmary, Hughes, Craig E., Mori, Jun, Sevcik, Carlos, D'suze, Gina and Watson, Steve P. (2011) Tityus discrepans scorpion venom activates platelets through GPVI and a novel Src-dependent signaling pathway. Platelets, 22 (3). pp. 165-172. ISSN 0953-7104 doi:

Hughes, Craig E., Navarro-Núñez, L., Finney, B. A., Mourão-Sá, D., Pollitt, Alice Y. and Watson, S. P. (2010) CLEC-2 is not required for platelet aggregation at arteriolar shear. Journal of Thrombosis and Haemostasis, 8 (10). pp. 2328-2332. ISSN 1538-7933 doi:

Hughes, Craig E., Pollitt, Alice Y., Mori, Jun, Eble, Johannes A., Tomlinson, Michael G., Hartwig, John H., O'Callaghan, Christopher A., Fütterer, Klaus and Watson, Steve P. (2010) CLEC-2 activates Syk through dimerization. Blood, 115 (14). pp. 2947-2955. ISSN 1528-0020 doi:

Spalton, J C, Mori, J, Pollitt, A Y, Hughes, C E, Eble, J A and Watson, S P (2009) The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets. Journal of thrombosis and haemostasis : JTH, 7 (7). pp. 1192-9. ISSN 1538-7836

Grygielska, B, Hughes, C E and Watson, S P (2009) Molecular basis of platelet activation by an alphaIIbbeta3-CHAMPS peptide. Journal of thrombosis and haemostasis : JTH, 7 (2). pp. 339-46. ISSN 1538-7836

Hughes, C E, Auger, J M, McGlade, J, Eble, J A, Pearce, A C and Watson, S P (2008) Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2. Journal of thrombosis and haemostasis : JTH, 6 (12). pp. 2152-9. ISSN 1538-7836

Riba, R, Hughes, C E, Graham, A, Watson, S P and Naseem, K M (2008) Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor gamma chain complex. Journal of thrombosis and haemostasis : JTH, 6 (6). pp. 1012-20. ISSN 1538-7836

Pears, Catherine J., Thornber, Kelly, Auger, Jocelyn M., Hughes, Craig E., Grygielska, Beata, Protty, Majd B., Pearce, Andrew C. and Watson, Steve P. (2008) Differential roles of the PKC novel isoforms, PKCδ and PKCε, in mouse and human platelets. PLoS ONE, 3 (11). e3793. ISSN 1932-6203 doi:

Hughan, Sascha C, Hughes, Craig E, McCarty, Owen J T, Schweighoffer, Edina, Soultanova, Izoumroud, Ware, Jerry, Tybulewicz, Victor L J and Watson, Steve P (2007) GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk. Arteriosclerosis, thrombosis, and vascular biology, 27 (2). pp. 422-9. ISSN 1524-4636

Dhanjal, Tarvinder S, Ross, Ewan A, Auger, Jocelyn M, McCarty, Owen J T, Hughes, Craig E, Senis, Yotis A, Buckley, Chris D and Watson, Steve P (2007) Minimal regulation of platelet activity by PECAM-1. Platelets, 18 (1). pp. 56-67. ISSN 0953-7104

Suzuki-Inoue, Katsue, Hughes, Craig E, Inoue, Osamu, Kaneko, Makoto, Cuyun-Lira, Olga, Takafuta, Toshiro, Watson, Steve P and Ozaki, Yukio (2007) Involvement of Src kinases and PLCgamma2 in clot retraction. Thrombosis research, 120 (2). pp. 251-8. ISSN 0049-3848

García, Angel, Senis, Yotis A, Antrobus, Robin, Hughes, Craig E, Dwek, Raymond A, Watson, Steve P and Zitzmann, Nicole (2006) A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter. Proteomics, 6 (19). pp. 5332-43. ISSN 1615-9853

Book or Report Section

Pollitt, Alice Y., Hughes, Craig E. and Watson, Steve P. (2013) GPVI and CLEC-2. In: Michelson, Alan D. (ed.) Platelets. 3rd edition. Academic Press, Amsterdam, pp. 215-231. ISBN 9780123878373 doi:

Conference or Workshop Item

Yu, Ting Y., Finney, Brenda A., Hughes, Craig E., Dehghani, Hamid, Claridge, Ela and Thomas, Steve G. (2013) Three dimensional analysis of cardiovascular development in mouse embryos using X-ray microcomputed tomography. In: Microscopy and Analysis.


Hughes, Craig E. (2010) Comparison of CLEC-2 and GPVI signaling in platelets: the role of adaptor proteins. PhD thesis, University of Birmingham.

This list was generated on Fri Dec 1 15:27:33 2023 UTC.

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