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Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2.

Hughes, C. E., Auger, J. M., McGlade, J., Eble, J. A., Pearce, A. C. and Watson, S. P. (2008) Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2. Journal of thrombosis and haemostasis : JTH, 6 (12). pp. 2152-9. ISSN 1538-7836

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Abstract/Summary

The results demonstrate that Gads plays a key role in linking the adapter LAT to SLP-76 in response to weak activation of GPVI and CLEC-2 whereas LAT is required for full activation over a wider range of agonist concentrations. These results reveal the presence of a Gads-independent pathway of platelet activation downstream of LAT.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences > Biomedical Sciences
ID Code:44581

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