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GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk.

Hughan, S. C., Hughes, C. E., McCarty, O. J. T., Schweighoffer, E., Soultanova, I., Ware, J., Tybulewicz, V. L. J. and Watson, S. P. (2007) GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk. Arteriosclerosis, thrombosis, and vascular biology, 27 (2). pp. 422-9. ISSN 1524-4636

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Abstract/Summary

We show that Syk is critical for lamellipodia formation on a range of immobilized proteins but that this can be overcome by addition of thrombin. Further, we reveal a novel role for GPVI in supporting thrombin-induced activation, independent of Syk and Src kinases.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences > Biomedical Sciences
ID Code:44584

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