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Kinetics analysis and automated online screening of aminocarbonylation of aryl halides in flow

Moore, J. S., Smith, C. D. and Jensen, K. F. (2016) Kinetics analysis and automated online screening of aminocarbonylation of aryl halides in flow. Reaction Chemistry & Engineering, 1 (3). pp. 272-279. ISSN 2058-9883

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To link to this item DOI: 10.1039/C6RE00007J

Abstract/Summary

Temperature, pressure, gas stoichiometry, and residence time were varied to control the yield and product distribution of the palladium-catalyzed aminocarbonylation of aromatic bromides in both a silicon microreactor and a packed-bed tubular reactor. Automation of the system set points and product sampling enabled facile and repeatable reaction analysis with minimal operator supervision. It was observed that the reaction was divided into two temperature regimes. An automated system was used to screen steady-state conditions for offline analysis by gas chromatography to fit a reaction rate model. Additionally, a transient temperature ramp method utilizing online infrared analysis was used, leading to more rapid determination of the reaction activation energy of the lower temperature regimes. The entire reaction spanning both regimes was modeled in good agreement with the experimental data.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:56244
Publisher:Royal Society of Chemistry

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