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Peptide hormones and lipopeptides: from self-assembly to therapeutic applications

Hutchinson, J. A., Burholt, S. and Hamley, I. W. (2017) Peptide hormones and lipopeptides: from self-assembly to therapeutic applications. Journal of Peptide Science, 23 (2). pp. 82-94. ISSN 1099-1387

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To link to this item DOI: 10.1002/psc.2954

Abstract/Summary

This review describes the properties and activities of lipopeptides and peptide hormones and how the lipidation of peptide hormones could potentially produce therapeutic agents combating some of the most prevalent diseases and conditions. The self-assembly of these types of molecules is outlined, and how this can impact on bioactivity. Peptide hormones specific to the uptake of food and produced in the gastrointestinal tract are discussed in detail. The advantages of lipidated peptide hormones over natural peptide hormones are summarised, in terms of stability and renal clearance, with potential application as therapeutic agents

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:69042
Publisher:European Peptide Society and John Wiley & Sons

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